Advancing Male Fertility Innovation at ASRM 2024

Path Fertility and its partners presented advancements in innovative fertility research at the American Society of Reproductive Medicine’s annual Congress & Expo. The 2024 conference brought together leading experts in the field to present the latest advancements in reproductive medicine and infertility. The presentations showcased new data and research in the following areas:

Economic Benefit of an Epigenetic Male Infertility Assessment

Presented by: Kristin Brogaard
Additional Authors: Lorry Schneider, Andy Olson
Published in Fertility and Sterility

Dr. Kristin Brogaard, co-founder and Chief Scientific Officer of Path Fertility, presented data for the economic utility of SpermQT. A more comprehensive assessment of male fertility with the epigenetic Sperm Quality Test (SpermQT) in the initial diagnostic workup shows cost and time savings for the patients, increased clinic margins, and significant cost savings for fertility benefits providers​​.

A Prospective Observational Trial of SpermQT Preliminary Results

Presented by: Dana Siegel
Additional Authors: Kristin Brogaard, Lorry Schneider, Alice Domar, Denny Sakkas, Kathleen Devine, Cassandra Roeca
Published in Fertility & Sterility

Dr. Dana Siegel, Clinical Fellow at Shady Grove Fertility, presented preliminary results from the SpermQT Prospective Observational Trial (“SPOT Study”). Early data from this prospective study suggest that despite having a higher TMC, men with an abnormal SpermQT result have fewer pregnancies after IUI than those with a normal score​​.

AlphaSperm Supplement Induced Epigenetic Reprogramming in Sperm

Presented by: Seth Parks
Additional Authors: Ryan Miller, Lily Millar, Kristin Brogaard, Paul Turek, Tim Jenkins
Published in Fertility and Sterility

We teamed up with AlphaSperm to investigate how the AlphaSperm supplement might impact sperm DNA methylation, and potentially affect fertility. The analysis provides strong evidence that sperm DNA methylation can be altered at biologically significant loci by supplementation with AlphaSperm.

Future advancements

These presentations demonstrate our focus on innovative, non-invasive diagnostics for the evolving needs in reproductive healthcare. Future advancements will further demonstrate the clinical and economic utility of the innovative products we develop in the coming years.

Path Fertility, is setting new standards in male fertility research and product development with a mission to raise the standard of care in reproductive health.


Kristin Brogaard, PhD

Kristin Brogaard, PhD is Co-founder and CSO of Inherent Biosciences, a molecular diagnostics company at the intersection of epigenetics and AI. Dr. Brogaard is an experienced molecular biologist, study director, and operations manager for early stage biotech startups. She received her PhD in Molecular Biology from Northwestern University developing novel epigenetic technologies. She subsequently worked with Dr. Leroy Hood, a pioneer in personalized medicine technologies, first as a post-doc and then as a colleague launching a novel scientific wellness start-up, Arivale. Dr. Brogaard has broad business experience that includes launching and scaling the health startup, Arivale. Additionally, Dr. Brogaard was the Director of Program Management at Arivale managing all strategic projects with a highly qualified team of program and project managers.

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